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KMID : 1123820070090020013
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Health & sports medicine
2007 Volume.9 No. 2 p.13 ~ p.20
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Brief review of muscle hypertrophy mechanism
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Kwon Young-Sub
So Ho-Sung
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Abstract
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Because of the topic’s physiological complexity, few personal trainers or instructors are thoroughly informed about how muscles actually adapt to, and grow to meet, the progressively
increasing overload demands of exercise.
Resistance training leads to trauma or injury of the cellular proteins in muscle. Exercise-induced muscle damage initiates an immune response, resulting in the influx of neutrophils, macrophages, etc. This prompts cell-signaling messages to activate satellite cells to begin a cascade of events leading to muscle repair and growth. Several growth factors, such as hepatocyte growth factor, leukemia inhibitory factor, and fibroblast growth factor, and endocrine factor like IGF-Ι, insulin, growth hormone, testosterone, and cortisol are involved that regulates the mechanisms of change in protein number and size within the muscle. The most adaptable tissue in the human body is skeletal muscle, which is remarkably remodeled after continuous
and carefully designed and priodization resistance exercise training programs.
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KEYWORD
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satellite cell, muscle growth, muscle trauma
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